Albumin is a hydrophilic protein mostly present in cells and body fluids and plasma albumin occupies approximately 56% - 60% of total plasma proteins. Plasma albumin is synthesized in the liver cells, plays an important role in maintaining blood osmotic pressure, and contributes the transfer of hydrophobic substances. Concentration of albumin in plasma is lowered in liver cirrhosis due to decreased biosynthesis, in malnutrition and pyrexial diseases due to increased consumption of albumin, and in renal damage due to secretion into urine. Meanwhile urinary albumin is increased since excretion of albumin into urine increased in glomerulonephritis, nephritic syndrome, and diabetic nephropathy. By measuring both albumin and total protein concentrations, the albumin-to-globulin ratio (A/G ratio) can be determined. The A/G ratio serves as a valuable marker for a range of conditions, including liver disease, kidney disease, nutritional disorders, multiple myeloma, and chronic inflammatory conditions. Urinary albumin measurements are commonly performed using the turbidimetric immunoassay (TIA) method. Fujifilm Wako offers TIA reagents optimized for automated analyzers compatible with specimens from rats, mice, and monkeys. For applications requiring higher sensitivity, ELISA is recommended. Fujifilm Wako also offers LabAssay™ Albumin, a biochemical assay kit based on the bromocresol green (BCG) method, providing a simple and rapid solution for measuring albumin in blood.