Quantitative NMR (qNMR) is a quantitative technique using the physical utilizing the property that the ratio of the signal area observed on the NMR spectrum is proportional to the ratio of the number of nuclei in the molecule. This holds true whether the nuclei are part of the same molecular structure or located in different molecular entities. From the above, qNMR is possible to determine the mass fraction of an analyte with a substance different from the analyte as a standard for qNMR. In addition, quantification of a wide variety of compounds is theoretically possible using only one standard for qNMR as long as the signals of the analyte and the standard do not overlap each other. In qNMR analysis, a mass fraction determination with metrological traceability is possible by using certified reference material (CRM) as a standard, calibrated balances for sample preparation, and evaluating measurement uncertainty.